Rare Genetic Disorders and Immune-dysregulation Research Group

The prevalence of rare genetic disorders in gulf region is high due to large family sizes, advanced maternal and paternal age, and high level of consanguinity in this area. These diseases have complex pathological presentation with no cure or standard treatment.  While many of these conditions are typically rare, in aggregate they account for a considerable morbidity and mortality in the community.

Our research group will follow a systematic approach to characterize rare genetic variations underlying primary immune deficiencies and predisposing to severe infectious disease such as COVID-19. The unknown genetic disorders will undergo series of clinical and experimental studies to describe their phenotype and genotype and to unravel their underlying molecular mechanism. Multi-omics approach will be used to profile and map the immune dysregulation network, to identify diagnostic and prognostic biomarkers, and to discover potential therapeutic targets. Precision medicine approach including drug repurposing, nanotechnology and genomics will be applied to find novel treatment for the identified and characterized genetic immune disorder.